These attributes in combination with safe clinical application of gold salts make this process a viable strategy for clinical translation. Recent reports evaluating this phenomenon in human cells and in murine models indicate that the use of gold ions for in situ formation of theranostic GNPs could greatly improve the delivery within dense biological tissues, increase efficiency of intracellular gold uptake, and specificity of GNP formation within cancer cells. Further, there is evidence of GNP formation in patients treated with gold salts (i.e., chrysiasis). Conversely, gold salts have been used in the clinic for nearly a century. However, currently there are no clinically approved injectable GNP formulations.
Gold nanoparticles (GNPs) have shown considerable potential in a vast number of biomedical applications.
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